\[3ab^{4} = 5 \Longrightarrow \ \ ab^{4} = \frac{5}{3}\]
\[- 12a^{2}b^{8} = - 12\left( ab^{4} \right)^{2} =\]
\[= - \frac{12 \cdot 25}{9} = - \frac{4 \cdot 25}{3} =\]
\[= - \frac{100}{3} = - 33\frac{1}{3}\]