\[x^{4} - 4x^{2} - 45 = 0\]
\[x^{2} = t \geq 0:\]
\[t^{2} - 4t - 45 = 0\]
\[D_{1} = 4 + 45 = 49\]
\[t_{1} = 2 + 7 = 9;\]
\[t_{2} = 2 - 7 = - 5 < 0.\]
\[x^{2} = 9\]
\[x = \pm 3.\]
\[Ответ:x = \pm 3.\]